Soon after he lands in America, Ali, a Muslim man from Pakistan, begins his search for his estranged wife, Nadia. On his journey, Ali meets with Teppei, a Japanese traveller hitchhiking his way across America, and Sarah, a local trailer park girl, who help him in his search. The three travellers succeed in finding Nadia, who, to Ali's dismay, is living a new life in Phoenix with another man. Ali spends the rest of his stay in America with Teppei and Sarah, anxiously wondering where his life is leading. In the brief time they are together, the three companions commit to helping one another. Ali, Teppei and Sarah begin a new journey, to find their own individual identities and in the process they find each other. Big River is a road movie, a tale about the borderless realm of friendship and its ability to transcend culture.